ClickCease Auvelity Approved by FDA as Novel Treatment for Depression | Easy Drug Card
Depression can be treated!

Auvelity Approved by FDA as Novel Treatment for Depression

Auvelity is a new, oral medication approved by the US Food and Drug Administration (FDA) for treatment of major depressive disorder (MDD) in adults. Auvelity combines two medications, dextromethorphan and bupropion, into one pill taken by mouth.

Dextromethorphan is an NMDA receptor antagonist and is commonly used as a cough syrup. NMDA receptors have been connected to the pathophysiology of various neurologic and psychiatric diseases such as Alzheimer’s disease, epilepsy, chronic pain syndrome, schizophrenia Parkinson’s disease, Huntington’s disease major depression, substance use disorders and anxiety. Another NMDA receptor antagonist recently approved by the FDA is esketamine (brand name Spravato), which is a nasal spray for treatment-resistant depression or depressive symptoms in adults with MDD with acute suicidal ideation or behavior.

Bupropion alone is available as a generic medication that can be used to treat depression or help quit smoking. Bupropion works by increasing the amount of norepinephrine and dopamine available in the brain. However, bupropion also effects as enzyme in the liver that break down other medications, including dextromethorphan. If you think of enzymes in the liver as Pac-Man eating up dots, bupropion makes Pac-Man move slower, so it takes longer for Pac-Man to get all the dots. In the same way, bupropion makes it take longer for the enzyme to metabolize dextromethorphan. Typically the effects of dextromethorphan last for only 3-8 hours, but with the addition of bupropion that time is prolonged.

Read our blog about other depression treatments here.

Both the GEMINI placebo-controlled study and the ASCEND study (which compared Auvelity to bupropion sustained-release tablets), looked at improvement in depression scores after 6 weeks. Depression scores began improving as early as week 1 in all groups, with Auvelity having a significant difference by week 2 when compared to both placebo and bupropion alone. The results are promising for Auvelity as a treatment option that may provide quicker results since it typically takes 4-5 weeks before noticeable changes in motivation and energy start to occur with other types of antidepressants. The most common side effects included dizziness, headache, diarrhea, sleepiness, dry mouth, sexual dysfunction, and excessive sweating.

Before prescribing Auvelity your doctor will need to assess your blood pressure, screen for history of bipolar disorder, mania, or hypomania, and make sure you are not receiving any other medications that contain bupropion or dextromethorphan. It is important to note that if someone has moderate to severe depression it is recommended to use both medications and psychotherapy, not just medications.

Auvelity will likely be available in late 2022. Auveltiy is also being studied for Alzheimer’s disease agitation and smoking cessation.



Save up to 80% on your prescriptions


Dr. Megan Onder

Dr. Megan Onder graduated from the University of Colorado School of Pharmacy and then completed a postgraduate year 1 (PGY-1) general practice residency and postgraduate year 2 (PGY-2) psychiatric pharmacy residency at the Central Virginia Veterans Affairs (VA) Healthcare System in Richmond, Virginia. Dr. Onder is a board certified psychiatric pharmacist and currently works in an outpatient pain management clinic at the Veterans Health Care System of the Ozarks in Fayetteville, Arkansas. She specializes in medication management for chronic pain, substance use disorders and mental health conditions (such as depression, PTSD, anxiety, bipolar disorder, and schizophrenia). Dr. Onder is passionate about serving veterans, empowering patients to take an active role in their healthcare, and improving access to affordable services.




Resource Guide

We know finding health insurance can be difficult and we hope this guide can help provide available resources to use today.

Pet Medications

Free discounts available for all pet owners on prescription medications at retail pharmacies across the U.S.

Bulk Discount Cards

We can ship multiple cards to satisfy your group or organization’s needs. Contact us with your specific needs.

Discount Drug Card

Free prescription discount drug card

In addition to discounts on your prescription drugs, you may be able to receive a discount on your over the counter medications such as vitamins or nasal spray.
Call 877-684-0032 for help.